NFKB1 and Hyperinsulinemia: Overnutrition induces hyperleptinemia and hyperinsulinemia by activating the tyrosine kinase Janus kinase (JAK) and the transcription factor signal transducer and activators of transcription (STAT) and IkB kinase (IKK)-β-NFκB signaling pathway through disruption of ER function (18).