Moreover, Wang and colleagues indicates that the activation of the AMPK/Foxa2 pathway can upregulate the expression of medium-chain acyl-CoA dehydrogenase, thereby promoting fatty acid oxidation and reducing lipid accumulation in nonalcoholic steatohepatitis (Wang et al., 2022). The gene discussed is FOXA2; the disease is metabolic dysfunction-associated steatohepatitis.