SH3D21 (SH3 domain containing 21) (Masoudi et al., 2019) was identified as a drug resistance maintenance gene in the Panc1 cell line, and knockdown of SH3D21 resulted in increased sensitivity of pancreatic cancer cells to gemcitabine, and it is hypothesized that the MYC pathway is associated with gemcitabine resistance. The gene discussed is MNMIP1; the disease is familial pancreatic carcinoma.