Barazas et al. (2018) performed LOF screening in a BRCA1-deficient cell line and found that the deletion of members of the CTC1-STN1-TEN1 complex led to PARPi resistance in BRCA1-deficient cells in vitro and in vivo by enhancing the repair of DSBs. Dev et al. (2018) identified two proteins, C20orf196 and FAM35A, in BRCA1-deficient cells by performing a whole genome screening in breast cancer. Here, BRCA1 is linked to breast carcinoma.