By performing a genome-wide screening for GECKOv2 in the MHCC97L cell line, Wei et al. (2019) found that PHGDH (phosphoglycerate dehydrogenase), an enzyme of the SSP (serine synthesis pathway), catalyzes the change from 3PG to 3PHP, and knockdown of the PHGDH gene sensitized the HCC cell line to sorafenib. Here, PHGDH is linked to hepatocellular carcinoma.