ARIH1 (Ariadne1 homolog), another ubiquitin ligase, also enhanced cisplatin resistance in normal and melanoma cells by modulating ARIH1, and the tumor suppressor neurofibrillary protein 2, NF2, enhanced cisplatin resistance in melanoma, but not in normal cells (Ko and Li, 2019). The gene discussed is NF2; the disease is melanoma.