By the chi square test, SERPINA1 expression was found to be highly negatively correlated with TNM stage, tumor stage, and distant metastasis (p = 0.020, 0.027, and 0.007, respectively), indicating that lower SERPINA1 mRNA expression levels were associated with poorer outcomes for CRC patients in the TCGA dataset (Table 2). The gene discussed is SERPINA1; the disease is colorectal carcinoma.