As further substantiation to the anti-tumor synergy of CNH-PG-mPT and BMS-1, histological examination revealed massive downregulation of PCNA and Ki67 expression, and upregulated expression of cleaved caspase 3 in tumors that received CNH-PG-mPT plus BMS-1, indicating occurrence of significant growth suppression and cell death (Fig. 3A). Here, CASP3 is linked to neoplasm.