CD274 and neoplasm: In light of the above evidence, it is reasonable to envision that blockade of PD-L1 in distressed tumors may give rise to several antitumor events, i.e. 1) impaired survival and proliferative potential of the tumor cells, 2) crippled control of the TAMs by the tumor cells, and 3) reactivation of TAMs towards an immunostimulatory phenotype.