PD-L1 in TAMs, while exercising immunosuppression on other immune cells via ligation with PD-1 [24], delivers an intrinsic signal that skews TAMs towards an immunosuppressive phenotype that can be reversed by PD-L1 blockade, eliciting TAMs-mediated tumor cytotoxicity [25, 26]. The gene discussed is CD274; the disease is neoplasm.