TAMs are widely present in various tumors, secreting a variety of cytokines such as epithelial growth factor (EGF), platelet-derived growth factor (PDGF), TGF, hepatocyte growth factor (HGF), and epithelial growth factor receptor (EGFR) family, and correlate with tumor growth, invasion, metastasis, and treatment-ineffectiveness [134–136]. This evidence concerns the gene HGF and neoplasm.