In the presence of SUSD6 and TMEM127, WWP2 mediates MHC-I ubiquitination as well as lysosomal degradation, thereby reducing MHC-I surface expression, loss of SUSD6 enhances MHC-I surface expression, which can promote the function of CD8+ T cells, thereby enhancing tumor immune surveillance [14]. This evidence concerns the gene SUSD6 and neoplasm.