There have been a number of combination therapies such as anti-PD-1/PD-L1(programmed death receptor 1/programmed cell death 1 ligand 1) combined with chemotherapy, radiotherapy, angiogenesis inhibitors, agonists of the co-stimulatory molecule, stimulator of interferon genes agonists, epigenetic modulators, or metabolic modulators and so on, showing superior efficacies and higher response rates in cancer treatment [6]. The gene discussed is CD274; the disease is cancer.