In the positive control analysis, significant associations of most lipid-lowering gene targets were identified with a decreased risk of coronary atherosclerosis and major coronary heart disease (CHD) events, except for APOB, CETP (only associated with reduced coronary atherosclerosis risks), and ANGPTL3 (not associated with either CHD or coronary atherosclerosis) (Fig. 3A). Here, ANGPTL3 is linked to coronary atherosclerosis.