Although there have been no prior studies on POSTN in fetal diseases or its expression in GS and AF, many studies have reported differential expression of POSTN (usually up-regulated) in heart valvulogenes [13], myocardial fibrosis [14], coronary artery disease [15], acute myocardial injury [16], allergic disease, inflammation, and cancer [17]. This evidence concerns the gene POSTN and Myocardial fibrosis.