In 2012, Richter et al. [20] studied the expression and role of ADPGK in tumor cells, and their results confirmed that ADPGK expression was not affected by hypoxic stimulation or hypoxia inducible factor-1, and overexpression of ADPGK did not increase the glycolytic levels in H460 and HCT116 cells. This evidence concerns the gene ADPGK and neoplasm.