Additionally, in a murine model of COPD, Rhinovirus (RV) infection induced CXCL-10 production by activated ST2/IL-33 signaling, causing prolonged infiltration of CD11b+/CD11c+ macrophages and CD8+ T cells in the lungs, which led to persistent lung inflammation [107]. The gene discussed is IL1RL1; the disease is chronic obstructive pulmonary disease.