During AD progression, microglia gradually switched from a homeostatic state to DAM, as evidenced by specific markers (e.g., Csf1, Itgax, Cd63, Ank, Axl, Igf1, Clec7a, Tyrobp, Ctsb, Ctsd, Ctsl, Cd9, Ctsz, Ccl6, Trem2, Spp1, Lpl, Cst7, Apoe). This evidence concerns the gene CLEC7A and Alzheimer disease.