CCND1 and neoplasm: The results showed that the expression levels of p-β-catenin, β-catenin, and CCND1 proteins were significantly increased in tumor tissues overexpressing CAMKK2, while the expression levels of p-β-catenin, β-catenin, and CCND1 proteins were decreased in the bufalin-treated group (Fig. 6C, D).