Virginie Eclache A et al. described a case of a 7-month-old patient with acute lymphoblastic leukemia involving four chromosomes, that is, 1, 4, 6, and 11, resulting in t(1;4;6;11)(q31;q27;q22;q23), and fluorescent in situ hybridization (FISH) confirmed mixed-lineage leukemia (MLL) gene rearrangement [17]. Here, KMT2A is linked to acute lymphoblastic leukemia.