In fact, rs4558409 is a subthreshold GWAS SNP associated with SCZ (p=0.007479 in PGC3) [36] and MDD (p=0.026) [40], and hyper-hydroxymethylation at the risk alternative T allele of rs4558409 (G/T), which reduced TF binding affinity and PLLP expression, might increase disease susceptibility. This evidence concerns the gene TF and major depressive disorder.