The gene signatures enriched in these processes were visualized between PCa (CCL21, THBS1, PTPRC, TNFSF14, CD3E), CAFs (CCL19, THBS1, CD3E) and TLN (CCL19, CTLA4, PTPRC, TNFSF14, ITK, CD3E) (Fig. 5I). This evidence concerns the gene CTLA4 and posterior cortical atrophy.