IGF1 and benign prostatic hyperplasia: Reports of some studies have shown that androgens such as dihydrotestosterone and testosterone caused BPH by promoting inflammation, oxidative stress [7] and by modulating the expression of growth regulatory proteins including insulin-like growth factor (IGF) [8], vascular endothelial growth factors (VEGF) [9, 10], and apoptosis suppressor, B-cell lymphoma-2 (Bcl-2) [7].