HMGCR and metabolic syndrome: The probable mechanism of curcumin in improving dyslipidemia is reducing the activity of lipoprotein lipase [41], suppressing the activity of fatty acid synthase (FAS), increasing the activity of fatty acid beta-oxidation [71], and increasing cholesterol catabolism through increasing the activity of the liver enzyme cholesterol 7-hydroxylase, which in turn, inhibits cholesterol synthesis by inhibiting the enzyme HMG-COA reductase [72].