DUSP1 and ovarian carcinoma: Moreover, the fact that CSGALNACT2 suppressed clonogenicity without impacting cellular proliferation suggests that it acts specifically on a subset of MAPK-mediated function pertaining to migration and colonization downstream of DUSP1.In IHC analysis of clinical normal ovarian tissue, ovarian cancer tissue, and metastatic tissue, the expression of CSGALNACT2 gradually decreased and significantly decreased in metastatic lesions, which was confirmed by qRT-PCR and RNA-seq.