Dual-luciferase report assay displayed that miR-512-5p overexpression combined with the mimics inhibited the luciferase activity of SOD2 wild-type in both H1229 and A549 cells, while the luciferase activity of SOD2 mutant did not change significantly (Fig. 4b), hinting at a direct interaction between miR-512-5p and the 3’UTR of SOD2. Moreover, SOD2 expression was determined in the NSCLC cells and tissues. This evidence concerns the gene SOD2 and non-small cell lung carcinoma.