Expression of IL-33 (interleukin-33), the top upregulated gene in the LoGI group (FC = 2.5), is lower in primary PC and mCRPC vs benign prostate tissue (P < 0.001), while expression of CHI3L1 (chitinase-3-like protein-1), the top downregulated gene in the LoGI group (FC = −10.98) is higher in primary PC vs benign prostate tissue (P < 0.001) (Fig. 4C). The gene discussed is IL33; the disease is pachyonychia congenita.