SIRT6 and neoplasm: Notably, no significant differences were detected between Delta16HER2/SIRT6-OE/Sirt6-/- and Delta16HER2 mice in terms of tumor-free survival (Fig. S1B), tumor multiplicity and volume (Fig. S1C–E), confirming that SIRT6-OE accounts for the phenotype of Delta16HER2/SIRT6-OE mice.