By contrast, at 30 weeks of age, Delta16HER2/SIRT6-OE cancers displayed a completely opposite signaling, showing a high pMAPK-p38/pERK ratio which is a marker of higher tumor dormancy and quiescence (Fig. S4C–E, additional blots in Supplementary Information)58,60,61. Here, SIRT6 is linked to neoplasm.