BDKRB1 and idiopathic pulmonary fibrosis: The most significant upregulation of CALM1/CALM2/CALM3, the downstream targets of the KNG1–BDKRB1 signaling and the upstream targets of the IL6–IL6R/IL6ST signaling, was detected in macrophages in the IPF lung (Fig. 7A, Supplementary Table S6).