For the 13 ligand (lung)–receptor (non-lung) pairs (from Step 2, Table 1), we found six such targets in the latent IPF-features (Table 3)—engulfment and cell motility 1 (ELMO1) as the downstream target for CXCL9–CXCR3, CXCL10–CXCR3, and CXCL11–CXCR3 pairs, calcium/calmodulin dependent protein kinase IV (CAMK4) as the downstream target for the IFNG–IFNGR1 and IFNG–IFNGR2 pairs, and phosphoenolpyruvate carboxykinase 1 (PCK1) as the downstream target for the IL6–IL6R pair. The gene discussed is PCK1; the disease is idiopathic pulmonary fibrosis.