PCK1, one of the IPF disease-omics features, is a known signaling molecule for the IL6 (ligand)–IL6R/IL6ST (receptor) interaction (KEGG: hsa04151, PI3K-Akt signaling pathway), and it is expressed in the hepatic cells (Fig. 7). The gene discussed is IL6ST; the disease is idiopathic pulmonary fibrosis.