YOD1 and Huntington disease: We tested the effects of altering the activity of 32 genes, encoding DUBs belonging to the OTU, MJD, USP, UCH, or JAMM families, on mHtt-induced phenotypes and found that increased activity of the Yod1 (CG4603) gene, encoding the Drosophila ortholog of the human YOD1 protein, suppressed all tested phenotypes in the HD model.