YOD1 and Huntington disease: By performing GSEA we found that differentially expressed genes (DEGs) in Yod1 overexpressing flies are enriched in protein folding related GO BP terms that are also enriched in human presymptomatic HD striatal and cortical tissues, including 'de novo' posttranslational protein folding, chaperone-mediated protein folding, and response to unfolded protein8.