YOD1 and Huntington disease: We tested genetic interactions of a mutant Htt transgene with 32 genes encoding deubiquitinases belonging to five DUB protein families and found that overexpression of Yod1, a DUB belonging to the OTU (ovarian tumor) superfamily of cysteine proteases, reduced the degeneration of photoreceptor neurons, and improved motor performance, viability and longevity of HD flies.