In two typical NSCLC cell lines in which H1299 cells overexpress CCDC106 but A549 cells express less CCDC106, the expression of CCDC106 upregulates the expression of Cyclin A2 and Cyclin B1, promoting cell proliferation via an Akt-dependent signaling pathway4. The gene discussed is CCDC106; the disease is non-small cell lung carcinoma.