The results from the experiments using the mouse xenograft model, developed by subcutaneous injection of treated H1299 cells, showed that knockdown of HOMER3 decreased the expression of GABPB1 in xenografts, and GABPB1-overexpression reversed the inhibitory effect of shHOMER3 treatment on tumor growth (Fig. 8G–I). This evidence concerns the gene GABPB1 and neoplasm.