Interestingly, CT26 cells that were never injected into mice do not express Pf4, whereas CT26 primary tumor cells express Pf4 more than 50 × compared to the CT26 cells (Supplementary Fig. S6A), showing that the tumor microenvironment induces increased Pf4 gene expression in CT26 tumor cells. This evidence concerns the gene PF4 and neoplasm.