ARHGAP26 and Parkinson disease: With respect to neurodegenerative disease, it is notable that nearly all PD-associated mutations impact proteins that participate in mitochondrial quality control52,63, and GRAF1 was shown by others to be neuroprotective in a human Parkinson’s cell culture model (MPP + ‐treated dopaminergic neuroblastoma SK‐N‐SH cells)64.