In this study, we found that the hsa_circ_0001846 derived from ubiquitin-associated protein 2 (UBAP2) was highly expressed in PC tissues and cell lines, meanwhile a variety of biological function experiments showed that hsa_circ_0001846 knockdown inhibited the proliferation, invasion and migration abilities of PC to a certain extent, and slowed down the growth of tumor in vivo. This evidence concerns the gene UBAP2 and pachyonychia congenita.