Of note, the converse experiment, that is, depletion of RIF1 in shMcm6 cells, was precluded by the fact that the viability of shMcm6 cells was severely compromised upon viral infection with Rif1-specific sgRNAs or shRNAs, in line with the observation that cells with limiting MCM proteins are sensitive to stress53–55. The gene discussed is RIF1; the disease is viral infectious disease.