ORMDL3 and metabolic dysfunction-associated steatohepatitis: Taken together, the aberrant accumulation of the key obesogenic sphingolipids S1P and ceramides, together with excessive and sustained lipotoxic ER stress in the livers of ORMDL3TG male but not female mice, correlated with the sexual dimorphism of diet-induced non-alcoholic steatohepatitis induced by Ormdl3 overexpression.