Both male and female mice fed a Western diet gained significant weight compared to their chow-fed littermates, with greater weight gain in males than in females (Figure 2A,B and Supplemental Table 1) but neither a genotype effect nor diet x genotype interaction were observed, suggesting that, Ormdl3 overexpression did not significantly influence diet-induced obesity in either gender (Figure 2A,B). Here, ORMDL3 is linked to obesity due to melanocortin 4 receptor deficiency.