ORMDL3 and obesity due to melanocortin 4 receptor deficiency: To this end, globally overexpressing Ormdl3-Flag transgenic mice (ORMDL3TG) were fed a high fat, high carbohydrate with cholesterol diet (HFD), and high fructose-glucose drinking water (sugar water, SW) for 18 weeks (Figure 1C), which was previously shown to mimic a typical western diet and induce the development of obesity, fatty liver, and dyslipidemia [20].