Then, Tumor Immune Estimation Resource (TIMER) database (https://cistrome.shinyapps.io/timer/) indicated that RGS1 was negatively correlated with cancer purity in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) (both P < 0.001, supporting information Figure S2). Here, RGS1 is linked to lung adenocarcinoma.