Disruption of myelination has been found in various peripheral neuropathies, such as those congenital hypomyelination neuropathies, Charcot-Marie-Tooth (CMT) 1A, B, C, D, E, CMT4B, C, D, F and J.27 Interestingly, we did observe a decrease of PAK2 activity in a CMT1E (Trembler-J) mouse nerves (Supplementary Fig. 3). This evidence concerns the gene PAK2 and peripheral neuropathy.