Dysregulation of Shh signaling activity has been reported in epileptic seizures where increased Shh signaling and Shh expression were observed in the hippocampus of temporal lobe epilepsy patients and epileptic rodent models (Fang et al., 2011; Pitter et al., 2014; Zhang et al., 2017). Here, SHH is linked to temporal lobe epilepsy.