Furthermore, we found no causal relationship between HF-BUN [IVW: OR, 1.01(95% CI, 0.99–1.01), p = 0.13], HF-EGFR [IVW: OR, 1.00(95% CI, 1.00–1.00), p = 0.74] and HF-UACR [IVW: OR, 1.01(95% CI, 0.99–1.03), p = 0.20], which further supports the significance of our study(S10 Table). The gene discussed is EGFR; the disease is hydrops fetalis.