Overall, the pooled data from six subtypes (including thalassemias, thalassemias trait, sickle cell disease, sickle cell trait, G6PD deficiency, and G6PD trait) showed the number of incident cases (18,731,778 cases) and incidence rates (242.09 in 2019) of G6PD trait remained the highest among different subtypes of inherited anemias till 2019 (Fig. 2A, D, Table S6). The gene discussed is G6PD; the disease is sickle cell disease.