A different taxonomy to consider might be a new glioma family termed “De novo replication repair deficient high-grade glioma”, with unique types being the IDH-wildtype tumors occurring in adults as described in this study (mixture of sporadic and Lynch-associated), the IDH-mutant tumors occurring in adolescents and young adults (mostly Lynch-associated), and the IDH- and H3-wildtype tumors occurring in children (mostly CMMRD-associated). Here, IDH2 is linked to central nervous system cancer.