IDH2 and central nervous system neoplasm: Deconvolution of DNA methylation array data was performed with methylCIBERSORT using a custom CNS tumor signature matrix to estimate neoplastic cell and various tumor microenvironment cell fractions for 7 de novo RRD glioblastomas and 98 conventional IDH-wildtype glioblastomas, all of which were initial primary surgical resection specimens prior to any radiation, chemotherapy, or immunotherapy agents.