DNA methylation profiling of an IDH-wildtype glioblastoma in an adult that classifies as “Diffuse pediatric-type high grade glioma, RTK1 subtype, subclass A” using version 12.7 of the DKFZ Molecular Neuropathology classifier may be another indication to consider and evaluate for this subtype. This evidence concerns the gene IDH2 and central nervous system cancer.