In this study, we discovered that increased mRNA expression of C5orf34 was associated with an unfavorable prognosis in patients with CESC, KIRP, SARC, LIHC, MESO, THCA, THYM, KIRC, ACC, GBM, PCPG, KICH, LGG, UCEC, LUAD, and UVM. Here, C5orf34 is linked to cervical squamous cell carcinoma.