Specifically, the expression of FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, MTF1, GLS, CDKN2A, SLC31A1 and ATP7B was upregulated in HCC tissues versus normal tissues, while the expression of PDHB was downregulated (Figure 1A, all P < 0.05). The gene discussed is LIAS; the disease is hepatocellular carcinoma.