PDHA1 and non-small cell lung carcinoma: DLAT is the initiator of the TCA cycle, and overexpressed DLAT promotes glycolysis and inhibits the breakdown of pyruvate into acetyl-CoA instead of promoting the TCA cycle, thereby aggravating the malignant development of NSCLC [26]; PDHA1 plays a role in HCC cancer metastasis and clinical pathology.