Considering these three levels, five LncRNA-miRNA-mRNA (CYTOR-hsa-miR-125b-5p-CDKN2A, MIR4435-2HG-hsa-miR-125b-5p-CDKN2A, DANCR-hsa-miR-125b-5p-CDKN2A, CYTOR-hsa-miR-125b-5p-GLS, MIR4435-2HG-hsa-miR-125b-5p-GLS) axes were constructed and had significant prognostic value in HCC. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.