Throughout this research, the correlation among cuproptosis-related genes and the colorectal cancer prognosis was investigated through an analysis of public databases, for this reason, a prognostic model for colorectal cancer was developed utilizing cuproptosis-related genes, and further elucidated the specific mechanisms by which the risk gene COX17 and the protective gene DLAT affect immune cells through the level of a single-cell to improve the therapeutic efficacy and prognosis for colorectal cancer. The gene discussed is COX17; the disease is colorectal cancer.