EGR2 and neoplasm: Finally, we investigated the pathway variations among the two groups using GSEA and GSVA analysis showed that several pathways critical for the regulation of tumor proliferation, invasion, and immune evasion, including the MAPK pathway, WNT pathway, HYPOXIA pathway, and EGR2 and SOX10 mediated pathways, are upregulated in high RiskScore, and several studies demonstrate the involvement of a hypoxic environment in the formation of immunosuppressive TME [24].