Moreover, through in-depth analysis of CRGs, we discovered that elevated levels of COX17 expression were observed for the first time in CD4-CXCL13 T cells in CRC mediates T cell exhaustion and Treg infiltration, while DLAT activates anti-tumor immunity by reversing T cell exhaustion and inducing tumor cell pyroptosis. Here, COX17 is linked to colorectal carcinoma.