CD4 and neoplasm: We classified cells from CRC patients into 40 clusters, such as CD4+ T cells, CD8+ T cells, lymphocytes, phagocytes, monocytes, dendritic cells (DC), mast cells, natural killer (NK) cells, neutrophils, plasma cells, and B cells (Figure 9A), which demonstrated that COX17 presented a significant degree of expression in the tumor microenvironment while DLAT expression levels were low (Figure 9B, 9C).