More recently TGF-β/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signalling pathways, major inducers of transcriptional reprogramming, were shown to converge at several levels and were all required for a proliferative-to-invasive phenotype switch in melanoma development (Lüönd et al., 2021). The gene discussed is TGFB1; the disease is melanoma.