A number of studies also linked heparanase activity to the augmented INSR signaling in several types of malignant tumors (i.e., myeloma, breast carcinoma, synovial sarcoma) (Goldberg et al., 2017; Purushothaman et al., 2017; Cassinelli et al., 2018). This evidence concerns the gene HPSE and plasma cell myeloma.