Additionally, thought the N-acyl chain of ceramides has received much attention, recent advancements in our understanding of sphingoid base biosynthesis through SPT have provided new routes for studies, some of which have observed upregulation of the SPTLC3 subunit of serine palmitoyltransferase (SPT) in NAFLD and hepatocellular carcinoma (HCC) models (Yoshimine et al., 2015; Teng et al., 2019). The gene discussed is SPTLC3; the disease is metabolic dysfunction-associated steatotic liver disease.