In tumor immunity, some CD8+ T cells exhibit an exhausted state and become dysfunctional, during which CD8+ T cells upregulate the expression of many inhibitory receptors, such as CTLA4, PD1, TIM3, and LAG3, and lose the ability to produce effector cytokines or cytotoxic molecules (Speiser et al., 2016; Philip and Schietinger, 2022). The gene discussed is CD8A; the disease is neoplasm.