Therefore, we aimed to investigate the relationship between lipid profile (triglyceride, cholesterol, HDL-C and LDL-C), PCSK9 concentration, and oxidative stress markers such as SOD, GPx, malondialdehyde, glutathione, total antioxidant capacity, and total oxidant status levels in preeclampsia women. The gene discussed is PCSK9; the disease is preeclampsia.