Interestingly, there appears to be evidence of fibrosis with hypertrophy in the glomeruli of hACE2 mice administered with SP within 4 weeks post COVID-19 sequelae, as expected, since this will suggest that there is acute kidney injury (AKI) with preserved glomerular filtration rate (GFR), that can be reversed by iNOS blocker37. The gene discussed is NOS2; the disease is acute kidney injury.