The levels of serum MMP-9 were increased by SP but interestingly, the levels of ADAMTS13 (e.g., the decreased level is marker of venous thromboembolism, VTE) was decreased by SP injection in hACE2 mice, when compared with untreated hACE2 mice (Fig. 1). This evidence concerns the gene ADAMTS13 and venous thromboembolism.