We know that SARS-CoV-2 infection depends on ACE2 and TMPRSS2, the host cell’s factors, and hence can be successfully blocked by clinically proven inhibitors; however, our findings might help establish options for the prevention, and treatment, and to lessen the damaging viral effects on human health especially in the vulnerable people since unlike other SARS coronaviruses, the novel SARS-CoV-2 has proven to be highly deleterious to people, especially the ones with underlying co-morbidities/conditions such as diabetes, cardiovascular, renal, and respiratory disease conditions. The gene discussed is TMPRSS2; the disease is diabetes mellitus.