We are of the opinion that iNOS generates NPT and decreases BH4, eNOS activity and a disintegrin and metalloproteinase thrombospondin 13 domain (ADAMTS13), anti-thrombosis/anti-coagulant but at the same time activates urinary neutrophil gelatinase associated lipocalin2 (NGAL2, pro-thrombosis/pro-coagulant), and transmembrane serine proteinase S2 (TMPTSS2, proteolytic factor processing of COVID-19) and matrix metalloproteinases (MMPs), leading to renal dysfunction and failure18,40–43. The gene discussed is NOS2; the disease is COVID-19.