SRC and renal fibrosis: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (PP1) is a small molecular compound that can inhibit the phosphorylation of Src at Tyr 416 and thus can play a therapeutic role in a variety of diseases, such as renal fibrosis, ischemic stroke, and pulmonary arterial hypertension [11,14,15].