Our data support that YTY-containing ACE2, in the context of a dimeric fusion with the QMP albumin variant, demonstrates improved viral binding and blockage of cellular infection against Delta (B.1.617.2) and Omicron (B.1.1.529, BA.5, BQ.1.1, and XBB) variants, in comparison with WT ACE2. The gene discussed is ACE2; the disease is infection.