It uses HI to take into account the severity of abdominal pathology [9]. Peritoneal contamination, tissue necrosis, or intestinal ischemia are associated with elevated levels of lactate, neutrophil, and CRP (nominator of HI) and decreased levels of lymphocyte and albumin (denominator of HI); hence, the more severe the underlying sepsis due to abdominal pathology, the higher the HI. The gene discussed is CRP; the disease is Sepsis.