TNF and periodontal disorder: Once periodontal disease is established, lipopolysaccharides and inflammatory cytokines, particularly Interleukin (IL)-1β, Prostaglandin E2 (PGE2) and Tumor Necrosis Factor (TNF)-α enhance a biologic burden which initiates the onset and progression of atherogenesis and thromboembolic events (Slade et al., 2000).