In the lung tumors from VC-induced mice, the percentage of CD8+ tumor-infiltrating lymphocytes (TILs) was significantly increased upon PV-1 treatment (Figure 4A), and the production of granzyme B, TNF-α and IFN-γ by CD8+ cells were all significantly increased in these mice (Figures 4B-D). The gene discussed is CD8A; the disease is neoplasm.